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Plasmonic enhancement of molecular fluorescence
Felicia Tam1, Glenn P Goodrich, Bruce R Johnson
1Department of Physics and Astronomy, Rice University, 6100 Main Street, Houston, Texas 77005, USA.
Nano Letters
|January 30, 2007
Summary
Metallic nanoparticles significantly boost fluorescence in indocyanine green (ICG) dye molecules. This enhancement, over 50x, occurs when nanoparticle plasmon resonance matches ICG emission and scattering is high.
Area of Science:
- Nanophotonics and Molecular Spectroscopy
Background:
- Metallic nanoparticles influence light emission from nearby fluorophores.
- Understanding nanoparticle-fluorophore interactions is key for optical applications.
Purpose of the Study:
- To investigate how nanoparticle plasmon resonance and scattering affect fluorescence enhancement of indocyanine green (ICG).
- To determine optimal conditions for maximizing ICG fluorescence.
Main Methods:
- Experimental examination of indocyanine green (ICG) dye fluorescence.
- Utilizing metallic nanoparticles with varying plasmon resonance energies and scattering cross sections.
- Quantifying fluorescence enhancement factors.
Main Results:
- Fluorescence enhancement exceeding 50-fold was observed for ICG adjacent to metallic nanoparticles.
- Maximum enhancement occurred when nanoparticle plasmon resonance frequency matched the ICG emission frequency.
- A large nanoparticle scattering cross section was crucial for significant fluorescence amplification.
Conclusions:
- Metallic nanoparticles can dramatically enhance molecular fluorescence.
- Tailoring nanoparticle plasmon resonance and scattering properties is essential for optimizing fluorescence enhancement in ICG dye.
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