HLA antigens and Vogt-Koyanagi-Harada's disease

¹Zhongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou, China.

|March 1, 1991

Abstract:

Thirty patients with Vogt-Koyanagi-Harada's disease were typed for HLA-A and HLA-B antigenic determinants by a microlymphocytotoxicity technique. HLA-B22 antigen showed an increased frequency of 43.3% in the patient group (relative risk = 8.69; exact P < 0.0001; corrected P < 0.0025) compared with normal control group (frequency = 7.69%). This association suggests that immunogenetic factor may play an important role in the pathogenesis of Vogt-Koyanagi-Harada's disease.

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