Infantile digital fibromatosis
Christopher Talbot1, Tahir Khan, Matthew Smith
1School of Medicine, Stopford Building, University of Manchester, Manchester, UK. ChrisTalbot@doctors.org.uk
Journal of Pediatric Orthopedics. Part B
|February 3, 2007
Summary
Surgical excision effectively treated infantile digital fibromatosis on pedal digits in four infants, with no recurrences observed. This rare condition, typically affecting digits, may benefit from surgical management despite its benign nature.
Area of Science:
- Dermatology
- Pediatric Surgery
- Oncology
Background:
- Infantile digital fibromatosis is a rare juvenile fibromatosis presenting on the digits of infants and children.
- While often benign and prone to spontaneous regression, management strategies vary.
Observation:
- A case series details four infants with infantile digital fibromatosis affecting pedal digits.
- All patients underwent surgical excision of the lesions.
Findings:
- Surgical excision resulted in complete resolution of the fibromatosis in all four cases.
- No evidence of recurrence was noted during follow-up after surgical intervention.
Implications:
- Despite recommendations for conservative management due to the benign nature and potential for regression, surgical excision appears to be an effective treatment.
- Surgical intervention is a viable and appropriate option for managing infantile digital fibromatosis, particularly when located on pedal digits, to ensure complete resolution and prevent recurrence.
Related Concept Videos
01:09Introduction to Fibroblasts
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:11Fibril-associated Collagen
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...