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Updated: Jul 17, 2026

Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
Vaccine delivery methods using viral vectors
Andreas Bråve1, Karl Ljungberg, Britta Wahren
1Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, 171 82 Stockholm, Sweden.
Abstract:
Viral vectors have different capabilities as gene delivery vehicles for vaccines and immunotherapeutics. This review discusses selected viral vector systems and plasmid DNA and provides an overview of their specific characteristics, strengths, and limitations. The features, modes of viral entry and replication, expression of heterologous proteins, issues related to both preexisting and heterologous immunity, and vaccine strategies are discussed for the different vectors. Comparisons of the features and capabilities of the vectors are provided.
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