Related Experiment Video
Updated: Jul 17, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
[Severe anterior myocardial infarction caused by amphetamine abuse]
Lars Peter Riber Zebis1, Thomas Decker Christensen, Morten Bøttcher
1Arhus Universitetshospital, Skejby Sygehus, Hjerte-lunge-karkirurgisk Afdeling T. lrz@post.tele.dk
Abstract:
We present a case showing that intake of amphetamine can cause severe anterior myocardial infarction with acute severe pump failure. Acute angiography revealed massive proximal thrombotic occlusion of the LAD, the first diagonal branch and septal branches in a 28-year-old man. Thrombectomy, balloon dilation and stenting were performed. Spasm thrombus interplay was found to be the likely mechanism. Due to the massive infarction, extremely depressed left ventricular performance and hemodynamic instability, the patient underwent successful heart transplantation. The patient was readmitted to hospital six months later due to chronic vascular rejection of the heart, which lead to the death of the young man.
Related Concept Videos
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...
Acute Coronary Syndrome I: Introduction
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...

