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Updated: Jul 17, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Identification of the arterial and cardiopulmonary total peripheral resistance baroreflex gain values from
R Mukkamala1, J Kim, Y Li
1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI, USA.
Abstract:
We have previously proposed a potentially noninvasive technique for determining the closed-loop gain values of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex systems by mathematical analysis of beat-tobeat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this paper, we describe an evaluation of the technique with respect to spontaneous hemodynamic variability measured from seven conscious dogs before and after chronic arterial baroreceptor denervation. We report that the technique correctly predicted the expected changes in the TPR baroreflex gain values induced by the baroreceptor denervation.
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