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[Viruses and brain tumors (author's transl)]
No Shinkei Geka. Neurological Surgery
|February 1, 1975
Summary
Human adenoviruses can cause tumors in rodents by transforming sensory neuronal precursors. These viruses induce specific tumor antigens in brain and retinal cells, indicating a direct link to oncogenesis.
Area of Science:
- Oncology
- Virology
- Neuroscience
Context:
- Human adenoviruses, including type 12, are oncogenic DNA viruses.
- Over 30 antigenic types of human adenoviruses have been identified.
- Eight serotypes are known to induce tumors in newborn rodents.
Purpose:
- To review the oncogenic potential of human adenoviruses and human papova JC viruses.
- To establish the causal relationship between human adenoviruses and malignant transformations.
- To investigate the target cells and tumor phenotype in adenovirus-induced neoplasms.
Summary:
- Human adenovirus type 12 causes medullo-epitheliomatous and retinoblastomatous neoplasms in rats.
- Tumors arise from sensory neuronal precursors in the brain and retina.
- Transformed cells consistently produce adenovirus tumor-specific (T) antigens.
Impact:
- Demonstrates a direct causal link between human adenoviruses and specific cancers.
- Identifies sensory microneuron precursors as target cells for adenovirus tumorigenesis.
- Highlights the role of viral T antigens in the development of brain and retinal tumors.