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Updated: Jul 17, 2026
07:20
Discovery and Synthesis Optimization of Isoreticular Al(III) Phosphonate-Based Metal-Organic Framework Compounds Using High-Throughput Methods
Published on: October 6, 2023
Approaches to high throughput physical organic chemistry
Christophe Portal1, Mark Bradley
1Combinatorial Centre of Excellence, School of Chemistry, West Mains Road, University of Edinburgh, Edinburgh, UKEH9 3JJ.
Organic & Biomolecular Chemistry
|February 8, 2007
Summary
High throughput (HT) techniques now accelerate physical organic chemistry research, enabling rapid reaction assessment and property profiling. These advanced methods offer new tools for analyzing monomer reactivity and Hammett parameters efficiently.
Area of Science:
- Physical Organic Chemistry
- Analytical Chemistry
Background:
- High throughput (HT) techniques are widely adopted for synthesizing large compound libraries.
- Recent advancements extend HT methods to physical organic chemistry applications.
Purpose of the Study:
- To provide an overview of emerging HT techniques in physical organic chemistry.
- To highlight the application of quantitative constructs for HT monomer reactivity profiling and Hammett parameter evaluation.
Main Methods:
- Application of diverse analytical tools, including mass spectrometry and image analysis.
- Development of HT tools for reaction assessment, kinetic, and thermodynamic measurements.
- Utilizing quantitative analytical constructs for profiling.
Main Results:
- Demonstrated feasibility of HT methods for physicochemical property profiling.
- Enabled efficient HT kinetic and thermodynamic measurements.
- Facilitated HT monomer reactivity profiling and Hammett parameter evaluation.
Conclusions:
- HT techniques offer powerful new capabilities for physical organic chemistry research.
- These methods significantly enhance the speed and scope of chemical analysis and property determination.
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