Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between non-protein-coding DNA and eukaryotic complexity.

Ryan J Taft1, Michael Pheasant, John S Mattick

  • 1ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, Australia.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 14, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FIRST-seq: a nanopore-based cDNA sequencing platform for RNA modification and structure profiling.

Genome biology·2026
Same author

Impact of patient-reported allergies and psychiatric history on lumbar interbody fusion outcomes: a retrospective cohort study in the United States.

Asian spine journal·2026
Same author

BLOC1S1 variants cause lysosomal and autophagic defects resulting in a hypomyelinating leukodystrophy with epileptic encephalopathy.

American journal of human genetics·2026
Same author

Advancing Neuropediatric Rare Disease Diagnosis Through Clinical Genome Sequencing.

Pediatric neurology·2026
Same author

Development of a comprehensive cardiovascular disease genetic risk assessment test.

Genetics in medicine open·2026
Same author

Specificity of the stabilizing interaction between intrinsically disordered protein sequences and G-quadruplexes in RNA.

Nucleic acids research·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

An Engineering Perspective on the Importance of Obtaining Operational Stability in Graduate School.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

The G-value paradox, concerning gene number and organism complexity, is explained by increased non-coding DNA, particularly introns. These intronic sequences are crucial for gene regulation in complex organisms.

Area of Science:

  • Molecular Biology
  • Genomics
  • Evolutionary Biology

Background:

  • The C-value and G-value paradoxes highlight inconsistencies between organismal complexity and cellular DNA content or gene number.
  • The G-value paradox, specifically, is challenging as protein-coding gene numbers do not correlate with developmental complexity.

Purpose of the Study:

  • To investigate the relationship between organismal complexity and non-coding DNA content.
  • To explore the role of introns in the G-value paradox and gene regulation in complex organisms.

Main Methods:

  • Analysis of sequenced genomes to quantify non-protein-coding DNA.
  • Examination of intron distribution in relation to gene expression and cellular states.

Main Results:

Related Experiment Videos

  • The proportion of non-protein-coding sequence consistently increases with organismal complexity.
  • Intron distribution is non-random, with larger introns overrepresented in highly expressed nervous system genes and in genes affected by embryonic stem cell differentiation and cancer.
  • Genes with substantial intronic sequences are linked to regulatory functions.

Conclusions:

  • The G-value paradox may be resolved by the expansion of non-coding DNA, including regulatory elements and non-coding RNAs.
  • Introns play a significant role in the regulatory complexity of higher organisms.