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Updated: Jul 17, 2026

Dithranol as a Matrix for Matrix Assisted Laser Desorption/Ionization Imaging on a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer
Published on: November 26, 2013
Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis
Christian Prühs1, Conrad Kunick
1Technische Universität Braunschweig, Institut für Pharmazeutische Chemie, Beethovenstrasse 55, D-38106 Braunschweig, Germany.
Abstract:
Darpones are a class of compounds with antiproliferative activity for cancer cells in vitro and in mouse models. In order to improve the solubility of the compounds, darpones with aminobutoxy side chains were synthesized. The new derivatives showed retained antiproliferative activity for cultured cancer cell lines. However, a change of the selectivity pattern in the in vitro cell line screening project of the American National Cancer Institute indicates that the solubilized derivatives might act through a different biological mechanism. A matrix COMPARE analysis of the cancer cell line screening data clearly distinguished darpones with and without solubilizing aminobutoxy side chains.
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