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[Spontaneous urogenital infection in macaques]

T I Kebu, E K Dzhikidze, M G Chikobava

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |February 15, 2007
    PubMed

    Insights

    Natural infections with urogenital tract pathogens like chlamydias and mycoplasms are common in macaques. Complicated pregnancies significantly increase infection rates and can lead to intrauterine transmission in newborns.

    Area of Science:

    • Veterinary Medicine
    • Primate Health
    • Microbiology

    Background:

    • Urogenital tract (UGT) infections in macaques can be caused by chlamydias, mycoplasms, ureaplasms, and trichomonades.
    • Assessing natural infection rates is crucial for understanding primate health and disease transmission.

    Purpose of the Study:

    • To determine the prevalence of natural urogenital tract infections in macaques.
    • To investigate the correlation between maternal pregnancy complications and offspring infection rates.
    • To explore potential intrauterine transmission of UGT pathogens.

    Main Methods:

    • Examined 198 macaques (rhesus, javan, lapunder) aged newborn to 25 years.
    • Utilized Polymerase Chain Reaction (PCR) assay for pathogen detection.
    • Analyzed nucleotide sequences of pathogens in deceased neonates and their mothers.

    Main Results:

    • A high infection rate (40%) was detected in healthy macaques.
    • Animals born from mothers with complicated pregnancies showed significantly higher pathogen detection rates (54.5% - 64.5%).
    • Mixed infections with 2-4 microorganisms were common in offspring from complicated pregnancies.
    • Weak, low-weight neonates were observed in infected older macaques (17-25 years).
    • Pathogen sequences in deceased neonates matched maternal sequences, suggesting intrauterine infection.

    Conclusions:

    • Macaques exhibit a substantial rate of natural urogenital tract infections.
    • Maternal pregnancy complications are strongly associated with increased pathogen detection in offspring.
    • Evidence suggests intrauterine transmission of urogenital pathogens from mother to fetus in macaques.

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