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[Follicle-stimulating hormone receptor polymorphism and ovarian function].
L Théron-Gérard1, M Pasquier, C Czernichow
1Service de Médecine de la Reproduction, Hôpital Jean-Verdier, Université Paris-XIII, avenue du 14-Juillet, 93140 Bondy, France. fredlucieg@free.fr
Gynecologie, Obstetrique & Fertilite
|February 16, 2007
Summary
Follicle-stimulating hormone receptor (FSHR) gene polymorphisms influence ovarian function. The Ser/Ser genotype at codon 680 is linked to lower FSH sensitivity, requiring higher exogenous FSH doses for ovarian stimulation.
Area of Science:
- Reproductive Endocrinology
- Human Genetics
- Molecular Biology
Context:
- The follicle-stimulating hormone receptor (FSHR) plays a crucial role in ovarian function.
- Common polymorphisms in the FSHR gene, particularly at codons 307 and 680, are frequently studied.
- These polymorphisms can influence receptor sensitivity and downstream signaling pathways.
Purpose:
- To investigate the association between FSHR gene polymorphisms and ovarian function.
- To determine the impact of specific FSHR genotypes on follicular phase length, FSH levels, and response to exogenous FSH.
- To explore the relationship between FSHR variants and conditions like premature ovarian failure and polycystic ovary syndrome.
Summary:
- The FSHR gene exhibits common polymorphisms, with Thr307Ala and Ser680Asn being most frequent and often linked.
- Women homozygous for the Ser (680) variant show higher follicular FSH levels and a longer follicular phase, indicating reduced FSH sensitivity.
- This genotype necessitates higher recombinant FSH doses for effective ovarian stimulation.
- No clear association was found between FSHR polymorphism and premature ovarian failure, while findings in polycystic ovary syndrome are inconsistent.
Impact:
- Understanding FSHR polymorphism can personalize ovarian stimulation protocols, potentially improving IVF outcomes.
- Identifies genetic factors influencing female reproductive health and response to fertility treatments.
- Highlights the need for genotype-guided FSH dosing in assisted reproductive technologies.
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