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Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9

Shen Liu1, Chaoqun Huang, Dawei Li

  • 1The Institute of Genetics, Fudan University, Shanghai, People's Republic of China.

Acta Biochimica Polonica
|February 22, 2007
PubMed

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The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...