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Updated: Jul 16, 2026
09:34
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Urea-bearing copolymers for guest-dependent tunable self-assembly
Amanda C Kamps1, Teddie Magbitang, Alshakim Nelson
1IBM Almaden Research Center, 650 Harry Road, San Jose, CA 95120, USA.
Chemical Communications (Cambridge, England)
|February 22, 2007
Summary
Reversible-deactivation radical polymerization synthesized novel urea-containing methyl methacrylate copolymers. These polymers effectively bind carboxylate isosteres, advancing materials for specific molecular interactions.
Area of Science:
- Polymer Chemistry
- Supramolecular Chemistry
Background:
- Carboxylate isosteres are important in medicinal chemistry and materials science.
- Developing specific binding materials is crucial for applications like drug delivery and sensing.
Purpose of the Study:
- To synthesize novel polymers capable of binding carboxylate isosteres.
- To explore the utility of urea-functionalized copolymers in molecular recognition.
Main Methods:
- Reversible-addition-fragmentation chain-transfer (RAFT) polymerization was employed.
- Methyl methacrylate was copolymerized with urea-bearing monomers.
Main Results:
- Urea-bearing methyl methacrylate copolymers were successfully synthesized.
- The synthesized copolymers demonstrated effective binding of carboxylate isosteres.
Conclusions:
- RAFT polymerization is a viable method for creating functional polymers for molecular binding.
- Urea-containing copolymers show promise for applications requiring selective recognition of carboxylate isosteres.
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