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Updated: Jul 16, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Herpes simplex infection in a juvenile orangutan (Pongo pygmaeus pygmaeus)
Maria J L Kik1, Jan H Bos, Jan Groen
1Section of Diseases in Exotic Animals and Wildlife, Department of Veterinary Pathobiology, Utrecht University, Yalelaan 1, Utrecht 3584 CL, The Netherlands.
Abstract:
A juvenile orangutan (Pongo pygmaeus pygmaeus) died after 8 days of diarrhea and vomiting. Necropsy showed petechial hemorrhages in the skin, the myocardium, and the peritoneal membranes. The lungs were hyperemic and edematous, and the liver and spleen were enlarged. Histologic changes consisted of interstitial pneumonia, hepatitis, and splenic hyperplasia. Numerous eosinophilic intranuclear inclusion bodies were visible in pulmonary epithelial cells, hepatocytes, and splenic endothelial cells. Electron microscopic examination revealed herpesvirus in hepatocyte nuclei. Polymerase chain reaction of liver tissue demonstrated the presence of a herpes simplex virus-1.
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