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Updated: Jul 16, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Anti-RNP immunity: implications for tissue injury and the pathogenesis of connective tissue disease
Michael P Keith1, Chantal Moratz, George C Tsokos
1Division of Rheumatology, Walter Reed Army Medical Center, Washington, DC, USA. mpkeith@bethesda.med.navy.mil
Abstract:
Certain autoantibodies are characteristic of autoimmune disease manifestations and contribute to organ pathology. The presence of high-titer antibodies to U1-RNP are associated with mixed connective tissue disease, although these antibodies may also be present in systemic lupus erythematosus and systemic sclerosis. However, the role of antibodies to U1-RNP in the pathogenesis of connective tissue disease remains unclear. Data from recent experimental studies promote the hypothesis that U1-RNP antibodies participate in both innate and adaptive immune responses, implicating them in the pathogenesis of connective tissue disease.
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