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In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent

C J Pan1, Z Y Shao, J J Tang

  • 1School of Materials Science and Engineering, SouthWest Jiaotong University, Chengdu 610031, China.

Journal of Biomedical Materials Research. Part A
|February 28, 2007
PubMed

Insights

Curcumin-eluting films loaded onto coronary stents show improved blood compatibility. These drug-eluting stents can prevent thrombus formation and reduce in-stent restenosis (ISR).

Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Drug Delivery Systems

Background:

  • In-stent restenosis (ISR) is a significant complication following coronary stenting, often caused by thrombus formation.
  • Curcumin exhibits antithrombotic properties, suggesting its potential for preventing ISR when locally released.

Purpose of the Study:

  • To fabricate and evaluate curcumin-eluting polylactic acid-co-glycolic acid (PLGA) films for enhanced blood compatibility.
  • To assess the potential of these films in preventing thrombosis for coronary stent applications.

Main Methods:

  • Fabrication of curcumin-eluting PLGA films.
  • In vitro evaluation of blood compatibility, including platelet adhesion, activation, and protein adsorption.
  • Structural analysis using Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS).
  • Contact angle and surface free energy measurements.

Main Results:

  • Curcumin incorporation into PLGA films did not alter curcumin's structure.
  • Curcumin-eluting films exhibited increased hydrophilicity and a higher polar fraction of surface free energy.
  • Significant reduction in platelet adhesion and activation on curcumin-loaded films.
  • Marked decrease in fibrinogen adsorption with curcumin loading.

Conclusions:

  • Incorporating curcumin into PLGA films significantly improves their blood compatibility.
  • Curcumin-eluting PLGA films demonstrate potential for fabricating drug-eluting stents to prevent thrombosis and ISR.

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