Related Experiment Videos
Noninactivation of a portion of Xq28 in a balanced X-autosome translocation
D Du Sart1, P Kalitsis, M Schmidt
1Murdoch Institute, VCGS, Royal Children's Hospital, Melbourne, Australia.
American Journal of Medical Genetics
|January 15, 1992
Abstract:
We present a balanced translocation (X;9) (q28;q21) in which the normal X chromosome is preferentially active. The derivative X chromosome is inactive in 93% of fibroblasts, but the X portion translocated onto chromosome 9 is not inactivated, as apparent from DNA methylation and chromosome replication patterns. Consequently, the patient is functionally disomic for the part of Xq28 distal to the locus LICAM.