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Suitability of cisplatin solutions for 14-day continuous infusion by ambulatory pump
M Hrubisko1, A T Mc Gown, J A Prendiville
1Cancer Research Institute, Slovak Academy of Sciences, Bratislava.
Cancer Chemotherapy and Pharmacology
|January 1, 1992
Abstract:
The stability of cisplatin (DDP) solutions (1 and 1.6 mg/ml in saline-mannitol) in plastic infusion bags was studied for up to 14 days at 25 degrees C, 37 degrees C and 60 degrees C. Small changes in the solution were observed, but no evidence of any decomposition product was seen. Some precipitation of DDP was seen in the 1.6-mg/ml solution at the lower temperatures. Fluid loss from the bags was significant at the higher temperatures.