Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autonomous hyperparathyroidism not associated with increased aluminum absorption.

M Z Mocan1, H Mocan, G S Fell

  • 1Renal Unit, Western Infirmary, Glasgow, Scotland.

Israel Journal of Medical Sciences
|January 1, 1992
PubMed
Summary

High parathyroid hormone (PTH) levels in dialysis patients do not increase aluminum absorption from the gut. This study suggests PTH may not enhance intestinal aluminum uptake in humans.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-κB Pathways and Reduced Osteogenic Potential.

Frontiers in molecular biosciences·2022
Same author

The E3 ubiquitin ligase Itch limits the progression of post-traumatic osteoarthritis in mice by inhibiting macrophage polarization.

Osteoarthritis and cartilage·2021
Same author

An update on the validation of whole slide imaging systems following FDA approval of a system for a routine pathology diagnostic service in the United States.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2017
Same author

Whole slide imaging: uses and limitations for surgical pathology and teaching.

Biotechnic & histochemistry : official publication of the Biological Stain Commission·2015
Same author

The variability of lead in dusts within the homes of young children.

Environmental geochemistry and health·2013
Same author

Advances in the regulation of osteoclasts and osteoclast functions.

Journal of dental research·2013

Area of Science:

  • Nephrology
  • Endocrinology
  • Gastroenterology

Background:

  • Patients with chronic renal failure often have elevated parathyroid hormone (PTH) levels.
  • Aluminum-based phosphate binders are used in hemodialysis patients, raising concerns about aluminum absorption.
  • The relationship between PTH levels and intestinal aluminum absorption is not well understood.

Purpose of the Study:

  • To investigate the effect of high versus low parathyroid hormone (PTH) levels on the intestinal absorption of aluminum.
  • To determine if PTH influences serum aluminum concentrations after oral aluminum hydroxide intake in patients undergoing regular hemodialysis.

Main Methods:

  • Eight patients on regular hemodialysis received a 6-g dose of aluminum hydroxide.
  • Serum aluminum levels were measured before and 5 hours after aluminum hydroxide ingestion.

Related Experiment Videos

  • Measurements were taken both before and after parathyroidectomy (PTX) to assess the impact of high and low PTH levels.

    • Main Results:

    • Plasma PTH levels decreased significantly after parathyroidectomy (PTX) (2,724 +/- 1,830 to 352 +/- 63 ng/l).
    • Serum aluminum levels did not show significant changes before or after PTX, nor did they differ significantly between the high and low PTH states.
    • Ingestion of aluminum hydroxide did not lead to a significant increase in serum aluminum levels in relation to PTH status.

    Conclusions:

    • High plasma parathyroid hormone (PTH) levels are not associated with increased serum aluminum concentrations in patients with chronic renal failure.
    • These findings suggest that PTH may not play a significant role in enhancing intestinal aluminum absorption in humans.
    • The study indicates that aluminum hydroxide absorption is not significantly affected by PTH levels in hemodialysis patients.