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Pregnancy-associated major basic protein in amniotic fluid.

K K Vernof1, S J Ory, G J Gleich

  • 1Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905.

Journal of Reproductive Immunology
|January 1, 1992
PubMed
Summary
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Pregnancy-associated major basic protein (PAMBP) is found in amniotic fluid during gestation. PAMBP in amniotic fluid is immunochemically identical to eosinophil granule major basic protein.

Area of Science:

  • Reproductive Biology
  • Immunology
  • Biochemistry

Background:

  • Pregnancy-associated major basic protein (PAMBP) is elevated in pregnant women's sera.
  • PAMBP is nearly identical to eosinophil granule major basic protein.

Purpose of the Study:

  • To determine if PAMBP is present in amniotic fluid.
  • To compare PAMBP in amniotic fluid with eosinophil granule major basic protein.

Main Methods:

  • Double antibody radioimmunoassay was used to test 112 amniotic fluid samples.
  • Immunochemical and physicochemical properties were analyzed.

Main Results:

  • 109 out of 112 amniotic fluid samples contained PAMBP levels > 400 ng/ml.
  • Amniotic fluid PAMBP was immunochemically identical to eosinophil granule major basic protein.

Related Experiment Videos

  • Physicochemical properties, including heat stability, were also identical.

    • Conclusions:

    • PAMBP is present in amniotic fluid throughout gestation.
    • Amniotic fluid PAMBP is indistinguishable from eosinophil granule major basic protein.