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Related Experiment Videos

Knee extension strength cutpoints for maintaining mobility.

Todd M Manini1, Marjolein Visser, Seok Won-Park

  • 1Institute on Aging, Department of Aging and Geriatric Research, Amsterdam, The Netherlands. tmanini@aging.ufl.edu

Journal of the American Geriatrics Society
|March 8, 2007
PubMed
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Identifying knee extensor strength thresholds can predict mobility limitations in older adults. Lower strength indicates higher risk for severe mobility limitation (SML) and mortality, aiding early intervention.

Area of Science:

  • Gerontology
  • Kinesiology
  • Public Health

Background:

  • Mobility limitation is a significant concern for older adults, impacting independence and quality of life.
  • Identifying early risk factors for severe mobility limitation (SML) is crucial for preventative strategies.

Purpose of the Study:

  • To establish specific knee extensor strength levels associated with high and low risk of developing SML in initially healthy older adults.
  • To determine if these strength cutpoints also correlate with gait speed and mortality risk.

Main Methods:

  • A prospective cohort study involving 2,784 older adults (mean age 73.6 years) with no prior mobility limitations.
  • Knee extensor strength was measured isokinetically, and participants were followed for a median of 5.9 years for SML onset.

Related Experiment Videos

  • Sex-specific deciles of relative knee extension strength were analyzed to identify predictive cutpoints for SML, gait speed, and mortality.

    • Main Results:

    • Sex-specific knee extensor strength cutpoints were identified. Low strength (e.g., <1.13 Nm/kg for men, <1.01 Nm/kg for women) indicated high SML risk.
    • Individuals in high- and moderate-risk strength categories showed significantly higher likelihood of slow gait speed and increased mortality risk.
    • These associations remained significant after adjusting for demographic factors, health behaviors, and medical conditions.

    Conclusions:

    • Objective knee extensor strength cutpoints serve as valuable markers for identifying older adults at risk of future mobility decline.
    • These findings support the use of strength assessment in clinical settings to stratify risk and guide interventions for preventing SML.