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Published on: January 11, 2020
Electrochemical transfer of (18)F from (18)O water to aprotic polar solvent
Fuminori Saito1, Yasuyuki Nagashima, Akira Goto
1Institute of Physics, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan. Fuminori@youshi.c.u-tokyo.ac.jp
Abstract:
Electrochemical transfer of (18)F(-) from enriched [(18)O]-water to pure acetonitrile was investigated to develop a simple and effective synthesis of (18)F-radiopharmaceuticals. The transfer of (18)F is composed of two steps: first step is electro-deposition on a graphite anode and the next step is electro-emission into pure acetonitrile by inversing the polarity of the electric tension. A sufficiently high fraction of the electro-emission, 73%, was achieved. The electrochemical transfer of (18)F to aprotic polar solvents without any additives, such as phase transfer catalysis, will make the synthesis of diverse (18)F-radiopharamceuticals simple and easy.
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