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Updated: Jul 16, 2026
06:46
Using Herbal-Cake-Separated Moxibustion for the Treatment of Rats with Chronic Renal Failure
Published on: December 22, 2023
[Acute renal failure caused by plant extract].
Katalin Vágási1, Péter Degrell, István Késoi
1Pécsi Tudományegyetem, Altalános Orvostudományi Kar II. Belgyógyászati Klinika és Nephrológiai Centrum, Pécs, Hungary.
Orvosi Hetilap
|March 9, 2007
Summary
Guarana, a popular herbal supplement, may cause acute kidney and liver failure, even when combined with common painkillers. This case highlights the potential dangers of unregulated supplements.
Area of Science:
- Nephrology
- Toxicology
- Pharmacology
Background:
- Guarana (Paullinia cupana) is a widely consumed herbal product, often found in energy drinks and supplements.
- Non-steroid anti-inflammatory drugs (NSAIDs) are common analgesics with known potential side effects.
- The combined nephrotoxic potential of herbal supplements and NSAIDs is not fully understood.
Observation:
- A 30-year-old female presented with 48 hours of anuria (lack of urine production).
- She reported chronic use of Guarana products and occasional use of parenteral NSAIDs.
- Clinical evaluation revealed acute renal and hepatic failure.
Findings:
- Renal biopsy confirmed acute tubular necrosis, indicating severe kidney damage.
- The patient required temporary dialysis for kidney support.
- Following treatment, her renal function gradually recovered with polyuria (excessive urine production).
Implications:
- This case underscores the potential nephrotoxicity and hepatotoxicity of Guarana, especially with concurrent NSAID use.
- It highlights the risks associated with over-the-counter (OTC) herbal products and supplements.
- Healthcare providers should inquire about OTC supplement use when evaluating patients with acute organ failure.
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