Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Matrix-metalloproteinases and glaucoma].

Cristina Malcea1, Cornel Stefan

  • 1Secţia Clinică de Oftalmologie, Spitalul clinic de Urgentă Militar Central.

Oftalmologia (Bucharest, Romania : 1990)
|March 10, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Management of Complicated Chronic Uveitis: A Case Report.

Romanian journal of ophthalmology·2025
Same author

A Case Series of Serious Adverse Events Following Anti-VEGF Intravitreal Injections.

Romanian journal of ophthalmology·2025
Same author

The 79th Annual Meeting of the European Board of Ophthalmology, alongside the UEMS Meeting.

Romanian journal of ophthalmology·2024
Same author

Chromovitrectomy.

Romanian journal of ophthalmology·2018
Same author

Glaucoma after chemical burns and radiation.

Romanian journal of ophthalmology·2018
Same author

Matrix regenerative therapy.

Romanian journal of ophthalmology·2018
Same journal

[Macular serpiginous choroiditis complicated by macular hole].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Therapeutic approach in persistent diabetic macular edema].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Preliminary results of treatment with aflibercept].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

MANAGEMENT OF DIABETIC RETINOPATHY, PREVALENCE AND CLINICAL CLASSIFICATION.

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Changes in intraocular pressure depending on posture].

Oftalmologia (Bucharest, Romania : 1990)·2015
Same journal

[Treatment for penetrating wound caused by metallic intraocular foreign body].

Oftalmologia (Bucharest, Romania : 1990)·2015
See all related articles

This study investigated matrix-metalloproteinases (MMP-2 and MMP-9) in glaucoma patients undergoing surgery. Findings may inform future treatment strategies for primary open angle glaucoma.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Biochemistry

Background:

  • Primary open angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Filtrating surgery is a common intervention for advanced POAG.
  • Matrix-metalloproteinases (MMPs) play a role in tissue remodeling and extracellular matrix degradation.

Purpose of the Study:

  • To analyze the activity of matrix-metalloproteinases (MMP-2 and MMP-9) in patients with POAG undergoing filtrating surgery.
  • To investigate potential differences in MMP activity based on topical prostaglandin analog treatment.

Main Methods:

  • Prospective study of 27 eyes with POAG undergoing filtrating surgery.
  • Patients were divided into three groups based on topical prostaglandin analog treatment (travoprost, latanoprost, or no prostaglandin analog).

Related Experiment Videos

  • Surgical tissue fragments were analyzed for MMP-2 and MMP-9 expression using immunohistochemistry (streptavidin-biotin-peroxidase method).

    • Main Results:

    • Immunohistochemical analysis revealed the presence of MMP-2 and MMP-9 in the surgical fragments.
    • Specific quantitative results regarding MMP levels and their correlation with treatment groups were obtained (details not provided in abstract).

    Conclusions:

    • Matrix-metalloproteinases (MMP-2 and MMP-9) are present in the tissues of patients with primary open angle glaucoma undergoing filtrating surgery.
    • Further research is warranted to elucidate the precise role of these MMPs in POAG pathogenesis and their modulation by prostaglandin analogs.