Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Flaxseed reduces plasma cholesterol levels in hypercholesterolemic mouse models.

Michael A Pellizzon¹, Jeffery T Billheimer, Leanne T Bloedon

¹M.D., Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, 421 Curie Blvd., BRB II/III, Philadelphia, PA 19104-6160, USA.

Journal of the American College of Nutrition

|March 14, 2007

Summary

Whole ground flaxseed effectively lowers plasma and hepatic cholesterol in mouse models. Its lipid-lowering effects are not mediated by hepatic genes, suggesting impacts on cholesterol and bile acid absorption.

Related Concept Videos

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

The New England journal of medicine·2017

Same author

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Nature genetics·2017

Same author

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress.

Cell reports·2017

Same author

Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease.

Circulation research·2017

Same author

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.

The Journal of clinical investigation·2017

Same author

Hepatic protein phosphatase 1 regulatory subunit 3B (Ppp1r3b) promotes hepatic glycogen synthesis and thereby regulates fasting energy homeostasis.

The Journal of biological chemistry·2017

Area of Science:

Nutritional Science
Biochemistry
Genetics

Background:

Western diets are associated with dyslipidemia.
Flaxseed is a potential dietary intervention for managing lipid profiles.
Understanding flaxseed's mechanism of action is crucial for its therapeutic application.

Purpose of the Study:

To investigate the effects of whole ground flaxseed on plasma and hepatic lipids.
To examine flaxseed's impact on hepatic gene expression in specific mouse models.
To elucidate the mechanism behind flaxseed's lipid-lowering properties.

Main Methods:

Utilized human apolipoprotein B-100 transgenic (hApoBtg) mice and LDL receptor knockout (LDLr(-/-)/apobec(-/-)) mice fed a Western diet.
Administered whole ground flaxseed (20% w/w) for 21 days to assess its effects on lipid profiles.

More Related Videos

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Related Experiment Videos

Last Updated: Jul 16, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

Analyzed plasma and hepatic lipids and key hepatic gene expression.

Main Results:

Flaxseed significantly reduced plasma total cholesterol (TC) and non-high-density lipoprotein cholesterol (non-HDL-C) in both mouse models.
Significant reductions in hepatic cholesterol were observed in both hApoBtg and LDLr(-/-)/apobec(-/-) mice.
Flaxseed did not alter the expression of major hepatic lipogenic genes.

Conclusions:

Whole ground flaxseed demonstrates potent cholesterol-lowering effects in relevant mouse models.
The lipid-lowering mechanism of flaxseed appears independent of hepatic gene regulation.
Findings suggest flaxseed may influence cholesterol absorption and/or bile acid reabsorption.