Related Experiment Video
Updated: Jul 16, 2026
Measuring DNA Damage and Repair in Mouse Splenocytes After Chronic In Vivo Exposure to Very Low Doses of Beta- and Gamma-Radiation
Published on: July 3, 2015
Vulnerability of folate in plasma and bone marrow to total body irradiation in mice
Kaori Endoh1, Masahiro Murakami, Keizo Umegaki
1Department of Domestic Science, Kyoritsu Women's University, Chiyoda-ku, Tokyo, Japan.
Purpose:
To examine how folate status in a body is influenced by oxidative stress.
Material And Methods:
Mice were given total body irradiation (TBI) by X-ray, and changes in the concentration of folate were compared to those in vitamins C and E.
Results:
In a time-dependent study, folate in plasma and bone marrow decreased from 5 h until 120 h post-TBI at 3 Gy. Folate in plasma and bone marrow decreased in a dose-dependent manner at 24 h. Marked decreases of vitamins C and E were also detected in bone marrow, but not in plasma even at 10 Gy of TBI. The susceptibility of plasma folate by irradiation was confirmed by an in vitro exposure study. Neither vitamins C and E nor folate were decreased in the liver by TBI.
Conclusion:
It is suggested that folate is vulnerable to oxidative stress, and folate may need to be evaluated, particularly for TBI or radiotherapy.
Related Concept Videos
02:59Biological Effects of Radiation
01:35Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...