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Updated: Jun 26, 2026
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
[Study on the expression of matrix metalloproteinase-12 and NM_002426 in squamous laryngeal carcinoma]
Weisong Liu1, Cheng Xiang, Shenshan Jia
1Department of Head and Neck, Tumor Hospital, Harbin Medical University, Harbin,150040, China.
Objective:
Matrix metalloproteinases (MMPs) are key factors which influence the grades and/or metastasis of stereo tumour. There are short of research of MMP-12 now. The experiment is done to investigate the expression of MMP-12 and NM_002426, and relationship between the two genes and the biologic behavior in squamous laryngeal carcinoma.
Method:
Thirty pairs of specimens, include supraglottic carcinoma tissue and normal mucosa, were chosen. Three gene arrays, based on different kinds of malignant, were made to study NM_ 002426 at first, then immunohistochemical method were used to observe the difference of MMP-12 between tumour and normal mucosa, metastasis group and no-metastasis group.
Result:
NM_002426 express high ratio in all 3 chips, and have the highest mark in both mid-level and high-level malignant tissue. The immunohistochemical results showed that MMP-12 had significant difference between tumour and normal mucosa, metastasis group and no-metastasis group. The MMP-12 expression was unrelated to different malignant degree.
Conclusion:
NM_ 002426 has significant hyperplasia in squamous laryngeal carcinoma, which caused high expression of MMP-12,and it makes a main contribution to the carcinogenesis and metastasis of laryngeal carcinoma. MMP-12 and its gene overexpress may be a auxiliary diagnosis method.
