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[Expression of Endothelin-1 in laryngeal carcinoma]
Jian Zhang1, Wei Zhong, Wugen Luo
1Department of Otolaryngology-Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006,China. zhangjian115123@hotmail.com
Objective:
To study the expression and clinical significance of Endothelin-1 in laryngeal carcinoma.
Method:
Immunohistochemical (SP) method was used to detect the expression of Endothelin-1 in 30 cases of laryngeal carcinoma,20 cases of laryngeal benign lesions and 10 cases of. The relationship between the expression of Endothelin-1 and the clinic stage was analysed by SPSS12. 0 software. RESULT. The positive expression of Endothelin-1 in all three type tissues. There is a significant difference between the laryngeal carcinoma and the laryngeal benign lesions, the laryngeal carcinoma and the normal laryngeal mucous membrane, the laryngeal benign lesions and the normal laryngeal mucous membrane( P <0. 05). The highest expression of Endothelin-1 is in laryngeal carcinoma tissue. In laryngeal carcinoma tissue, the advanced clinical stage, the more higher expression of endothelin-1.
Conclusion:
Positive expression of Endothelin-1 in laryngeal carcinoma tissue was highest in three tissue. It may be play an important role in carcinogenesis and progress of laryngeal carcinoma.
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