Related Experiment Video
Updated: Mar 25, 2026

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
Published on: September 13, 2024
[Protective effects of minocycline against apoptosis of olfactory sensory neurons]
Fanglei Ye1, Xiangdong Guo, Weihua Lou
1Department of Otorhinolaryngology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou,450052, China. yefanglei@hotmail.com
Objective:
To investigate the protective effects of minocycline against apoptosis of olfactory sensory neurons induced by sinusitis.
Method:
Sixty adult SD rats were divided randomly into three groups: control group (group A), sinusitis group (group B) and intravenous injection of minocycline group (group C). The rats were sacrificed at 1,3,5 d and 7 d after surgery, and then the tissue sections of olfactory epithelium were stained and evaluated with hematoxylin and eosin (HE) and immunohistochemistry method.
Result:
The histopathological changes in maxillary sinus epithelium tissues observed with he staining microscopic examination in group B and C were worse than that in group A. Significant difference of the thickness of olfactory epithelium and Caspase-3 activity was demonstrated in group B and group C.
Conclusion:
The result demonstrated that minocycline could inhibit expression of Caspase-3 in rats with sinusitis.
More Related Videos
08:33Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
Published on: December 4, 2014
11:13Dissection of Adult Mouse Utricle and Adenovirus-mediated Supporting-cell Infection
Published on: March 28, 2012
Related Concept Videos
Olfaction
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure