Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

DNA bubble dynamics as a quantum Coulomb problem.

Hans C Fogedby1, Ralf Metzler

  • 1Department of Physics and Astronomy, University of Aarhus, DK-8000, Aarhus C, Denmark. fogedby@phys.au.dk

Physical Review Letters
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reversal of tracer advection and Hall drift in an interacting chiral fluid.

Physical review. E·2026
Same author

Anomalous statistics in the Langevin equation with fluctuating diffusivity: from Brownian yet non-Gaussian diffusion to anomalous diffusion and ergodicity breaking.

Reports on progress in physics. Physical Society (Great Britain)·2026
Same author

Anomalous diffusion and fluctuations in complex systems and networks.

Chaos (Woodbury, N.Y.)·2026
Same author

Fractional Brownian motion with mean-density interaction: A myopic self-avoiding fractional stochastic process.

Physical review. E·2025
Same author

The organization of serotonergic fibers in the Pacific angelshark brain: neuroanatomical and supercomputing analyses.

Frontiers in neuroscience·2025
Same author

Different behaviors of diffusing diffusivity dynamics based on three different definitions of fractional Brownian motion.

Physical review. E·2025
Same journal

Erratum: Bacterial Turbulence at Compressible Fluid Interfaces [Phys. Rev. Lett. 136, 138301 (2026)].

Physical review letters·2026
Same journal

Unveiling Light-Quark Yukawa Flavor Structure via Dihadron Fragmentation at Lepton Colliders.

Physical review letters·2026
Same journal

Adaptable Route to Fast Coherent State Transport via Bang-Bang-Bang Protocols.

Physical review letters·2026
Same journal

Topological Transition and Emergence of Elasticity of Dislocation in Skyrmion Lattice: Beyond Kittel's Magnetic-Polar Analogy.

Physical review letters·2026
Same journal

Pound-Drever-Hall Method for Superconducting-Qubit Readout.

Physical review letters·2026
Same journal

Coupling a ^{73}Ge Nuclear Spin to an Electrostatically Defined Quantum Dot in Silicon.

Physical review letters·2026
See all related articles

We explored DNA denaturation bubble dynamics, linking them to a Coulomb problem. This reveals how bubble survival depends on temperature, with unique behaviors at and around the melting point (Tm).

Area of Science:

  • Biophysics
  • Physical Chemistry
  • Statistical Mechanics

Background:

  • DNA denaturation involves the unwinding of double-stranded DNA.
  • Understanding bubble dynamics is crucial for DNA stability and function.
  • Existing models may not fully capture the statistical mechanics of denaturation dynamics.

Purpose of the Study:

  • To investigate the dynamics of denaturation bubbles in double-stranded DNA.
  • To derive expressions for bubble survival distribution W(t) across different temperatures.
  • To analyze the influence of temperature and potential interactions on DNA bubble stability.

Main Methods:

  • Formulating the dynamics using a Fokker-Planck equation.
  • Establishing an equivalence between the DNA denaturation problem and a Coulomb problem.

Related Experiment Videos

  • Deriving analytical expressions for the bubble survival distribution W(t).

    • Main Results:

    • The Fokker-Planck equation for bubble dynamics is equivalent to a Coulomb problem.
    • Below the melting temperature (Tm), survival distribution relates to repulsive Coulomb scattering states.
    • At Tm, a vanishing potential leads to a power-law tail with novel dynamic exponents.
    • Above Tm, dynamics are governed by the lowest bound state of an attractive potential.

    Conclusions:

    • The Coulomb problem analogy provides a powerful framework for understanding DNA bubble dynamics.
    • Temperature significantly alters bubble survival, with distinct behaviors below, at, and above Tm.
    • Critical exponents and potential interactions dictate DNA bubble stability and lifetime.