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Pattern of proton pump inhibitor calls to Texas poison centers, 1998-2004

Mathias B Forrester1

  • 1Epidemiology and Disease Surveillance Unit, Texas Department of State Health Services, Austin, Texas 78756, USA. mathias.forrester@dshs.state.tx.us

Journal of Toxicology and Environmental Health. Part A
|March 17, 2007
PubMed

Insights

Most proton pump inhibitor exposures, especially in children, can be safely managed at home. This study analyzed 2943 reported exposures, finding favorable outcomes in most cases.

Area of Science:

  • Toxicology
  • Pharmacology
  • Public Health

Background:

  • Limited data exists on managing adverse proton pump inhibitor (PPI) exposures.
  • PPIs are widely used medications, increasing the potential for accidental exposures.
  • Understanding exposure patterns is crucial for developing effective management strategies.

Purpose of the Study:

  • To analyze the distribution and characteristics of proton pump inhibitor exposures reported to Texas poison control centers.
  • To compare pediatric and adult patient demographics, exposure circumstances, and outcomes.
  • To identify trends in PPI-related adverse events and their management.

Main Methods:

  • Retrospective analysis of 2943 proton pump inhibitor exposure cases reported to Texas poison control centers from 1998 to 2004.
  • Categorization of exposures by patient age (pediatric vs. adult), substance involved (PPI alone vs. co-exposures), and other demographic and clinical factors.
  • Comparison of clinical characteristics and management outcomes between pediatric and adult populations.

Main Results:

  • Proton pump inhibitor (PPI) exposures accounted for a significant number of reported cases, with 62% involving PPIs alone.
  • Pediatric patients (age <= 5 years) constituted the majority (66%) of PPI-alone exposures.
  • Significant differences were observed between pediatric and adult patients regarding gender, exposure reason, site, management, clinical outcomes, and treatments.

Conclusions:

  • The majority of potentially adverse proton pump inhibitor exposures reported to poison control centers can be successfully managed at home with favorable outcomes.
  • Age is a significant factor influencing the characteristics and management of PPI exposures.
  • Further research into specific adverse effects and targeted interventions for pediatric PPI exposures may be warranted.

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