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Updated: Jul 16, 2026
10:52
Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets
Published on: August 13, 2016
Clockwise or anticlockwise? Turning the centriole triplets in the right direction!
Rustem Uzbekov1, Claude Prigent
1Cell Cycle Group, Department of Electron Microscopy, A.N. Belozersky Institute of Phisico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, Russia. Rustuzbekov@aol.com
FEBS Letters
|March 21, 2007
Summary
Centrosomes, crucial for cell processes and linked to human diseases, have complex structures. This review defines rules for normal centriole structure by analyzing common errors.
Area of Science:
- Cell Biology
- Molecular Biology
- Structural Biology
Background:
- Centrosomes are vital cytoplasmic assemblies comprising centrioles and pericentriolar material.
- Centrosome dysfunction is implicated in various human diseases.
- Knowledge of centrosome biochemistry is advancing, but structural details require clarification.
Purpose of the Study:
- To review common structural errors in centrioles.
- To establish a set of rules defining normal centriole structure.
- To bridge the gap between biochemical and structural understanding of centrosomes.
Main Methods:
- Literature review of published studies on centrosome structure.
- Analysis of electron microscopy data and structural models.
- Comparative analysis of normal and aberrant centriole architectures.
Main Results:
- Identification of recurring structural abnormalities in centrioles.
- Formulation of a standardized set of criteria for assessing centriole structural integrity.
- Distinction between biochemical and structural aspects of centrosome function.
Conclusions:
- Defining clear rules for centriole structure is essential for understanding its function.
- Recognizing structural errors aids in diagnosing diseases linked to centrosome defects.
- This framework supports future research into centrosome biology and disease pathology.
Related Concept Videos
01:13Centrioles and Centrosomes
Most animal cells comprise a pair of centrioles together called a centrosome. The cell duplicates its centrosome and contains two centrosomes side-by-side, which begin to move apart during the prophase. As the centrosomes migrate to two different sides of the cell, microtubules start extending from each centrosome toward the other end. The mitotic spindle is composed of the centrosomes and their emerging microtubules.
Near the end of the prophase, also called late prophase or "prometaphase,"...
Near the end of the prophase, also called late prophase or "prometaphase,"...
02:25Centrosome Duplication
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
02:25Centrosome Duplication
The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
02:11Forces Acting on Chromosomes
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis.
Microtubules and motor proteins exert two types of forces on...
Microtubules and motor proteins exert two types of forces on...
02:11Forces Acting on Chromosomes
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis.
Microtubules and motor proteins exert two types of forces on...
Microtubules and motor proteins exert two types of forces on...
02:13Determining the Plane of Cell Division
Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function.
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...
Animal cells
In animal cells, the cleavage furrow forms along the plane of cell division starting...