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Persistent erythema multiforme and CMV infection.

Molly Wanner1, Marlyanne Pol-Rodriguez, Ginette Hinds

  • 1Department of Dermatology, Massachusetts General Hospital, Harvard University, Boston, MA, USA. mwanner@partners.org

Journal of Drugs in Dermatology : JDD
|March 22, 2007
PubMed
Summary
This summary is machine-generated.

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Persistent erythema multiforme, a rare skin condition, is now linked to cytomegalovirus infection. This marks the first reported association, expanding the known triggers for this disorder.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Virology

Background:

  • Persistent erythema multiforme (PEM) is an uncommon mucocutaneous condition.
  • PEM has been associated with various infections, autoimmune diseases, and malignancies.
  • Previous reports link PEM to Epstein-Barr virus, herpes simplex virus, and hepatitis C virus.

Observation:

  • This case study details a patient presenting with persistent erythema multiforme.
  • The patient was diagnosed with a concurrent cytomegalovirus (CMV) infection.

Findings:

  • This is the first documented instance of persistent erythema multiforme associated with cytomegalovirus infection.
  • The findings suggest a potential etiological role for cytomegalovirus in PEM.

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Implications:

  • This discovery broadens the spectrum of known triggers for persistent erythema multiforme.
  • Further research is warranted to understand the pathogenetic mechanisms linking CMV and PEM.
  • Clinicians should consider cytomegalovirus screening in patients with unexplained persistent erythema multiforme.