Related Experiment Video
Updated: Jul 16, 2026
13:49
Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
Published on: December 6, 2017
Design and application of stimulus-responsive peptide systems.
Karuppiah Chockalingam1, Mark Blenner, Scott Banta
1Department of Chemical Engineering, Columbia University, New York, NY 10027, USA.
Protein Engineering, Design & Selection : PEDS
|March 23, 2007
Summary
Peptides and proteins change shape with stimuli like temperature and pH. This review highlights natural and designed systems for applications in biomaterials, drug delivery, and bionanotechnology.
Area of Science:
- Biochemistry and Materials Science
- Focuses on the molecular behavior of peptides and proteins and their application in advanced materials.
Background:
- Proteins and peptides naturally change conformation in response to environmental cues (temperature, pH, small molecules).
- This stimulus-responsive behavior is fundamental to biological processes.
- Exploiting this property enables the creation of advanced functional systems.
Purpose of the Study:
- To review prominent examples of natural and designed synthetic stimulus-responsive peptide systems.
- To highlight their applications in diverse research areas.
- To discuss future directions in the field.
Main Methods:
- Review of existing literature on natural and designed stimulus-responsive peptides.
- Categorization of systems based on their responsive mechanisms and applications.
- Discussion of protein engineering approaches for developing novel systems.
Main Results:
- Numerous natural and designed peptides exhibit stimulus-responsive conformational changes.
- These systems have demonstrated potential in biomaterials, nanodevices, biosensors, bioseparations, tissue engineering, and drug delivery.
- Directed evolution and combinatorial approaches are poised to expand the range of stimuli and applications.
Conclusions:
- Stimulus-responsive peptide systems offer versatile platforms for technological innovation.
- Continued research, particularly using advanced protein engineering, will drive the development of new peptides and proteins.
- These advancements will significantly impact fields like bionanotechnology and synthetic biology.
Related Concept Videos
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:23Modified-Release Drug Delivery Systems: Classification
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...