Related Experiment Video
Updated: Jul 16, 2026

Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
Published on: April 4, 2022
NURSE: Nitroglycerin Use: Revisiting Strategies for Efficacy
Natalie Nichols1, Debbie Oldford, Sandra Duke
1Queen Elizabeth II Health Sciences Centre, Halifax, NS. natalie.nichols@cdha.nshealth.ca
Abstract:
Sublingual nitroglycerin (SLN) is front-line therapy for the treatment of episodic stable angina discomfort. Anecdotal evidence gathered by advanced practice nurses in a cardiac pre-assessment clinic suggested that SLN was often overlooked by health care professionals as an integral component of angina self-management. A brief questionnaire exploring patients' knowledge and use of SLN was subsequently administered to 300 patients. Information gathered from the questionnaire indicated that patients are not consistently prescribed SLN for suspected or confirmed coronary artery disease. Knowledge deficits were evident concerning the proper dosage and administration of SLN, even in patients with a longstanding history of angina. Many were unaware of SLN prophylaxis and the concomitant use of topical nitrates. This paper will discuss practice implications for optimizing SLN therapy in angina self-management.
Related Concept Videos
Angina V: Nursing Management
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Angina IV: Management
Acute Coronary Syndrome V: Nursing Management
Drug Delivery: Enteral Route
Drugs in...
Aortic Regurgitation IV: Nursing Management
