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Published on: September 14, 2018
Gastrointestinal disorders in anaphylaxis.
Toshihiro Shirai1, Masashi Mori, Takahiro Uotani
1Department of Respiratory Medicine, Shizuoka General Hospital. tmjkshi@general-hosp.pref.shizuoka.jp
Anaphylaxis, a severe allergic reaction, can rarely lead to gastrointestinal issues like peptic ulcers and ischemic colitis. Prompt recognition of these rare complications is crucial for patient management.
Area of Science:
- Gastroenterology
- Allergy and Immunology
- Internal Medicine
Background:
- Anaphylaxis is a severe, potentially life-threatening systemic hypersensitivity reaction.
- Gastrointestinal manifestations of anaphylaxis are uncommon but can be serious.
- This report highlights rare gastrointestinal complications associated with anaphylaxis.
Observation:
- Two cases of anaphylaxis are presented, one induced by cefaclor and the other by pranoprofen.
- Both patients experienced abdominal pain approximately 10 hours after the onset of anaphylaxis.
- Endoscopic findings revealed severe peptic ulcers and ischemic colitis.
Findings:
- Anaphylaxis can be complicated by significant gastrointestinal mucosal lesions, including peptic ulcers and ischemic colitis.
- These gastrointestinal disorders developed several hours after the initial anaphylactic event.
- The findings underscore a potential link between anaphylaxis and subsequent gastrointestinal pathology.
Implications:
- Clinicians should consider the possibility of gastrointestinal mucosal lesions in patients presenting with abdominal pain following anaphylaxis.
- Awareness of these rare complications may improve diagnostic accuracy and patient outcomes.
- Further research may elucidate the mechanisms underlying anaphylaxis-induced gastrointestinal injury.
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