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Updated: Jul 16, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
MicroRNAs in search of a target
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Abstract:
As the number of known microRNAs (miRNAs) increases, and their importance in physiology and disease becomes apparent, the identification of their regulatory targets is a requisite for a full characterization of their biological functions. Computational methods based on sequence homology and phylogenetic conservation have spearheaded this effort in the last 3 years, but they may not be sufficient. Experimental studies are now needed to extend and validate the computational predictions and further our understanding of target recognition by miRNAs.
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