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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
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Optic neuropathy complicating multifocal choroiditis and panuveitis.

Jennifer E Thorne1, Susan Wittenberg, Sanjay R Kedhar

  • 1Department of Ophthalmology, the Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. jthorne@jhmi.edu <jthorne@jhmi.edu>

American Journal of Ophthalmology
|March 28, 2007
PubMed
Summary

Optic neuropathy is a rare complication of multifocal choroiditis and panuveitis (MFCPU). Treatment with corticosteroids and immunosuppressive drugs can prevent vision loss and recurrence of optic nerve inflammation.

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Multifocal choroiditis and panuveitis (MFCPU) can lead to serious ocular complications.
  • Optic neuropathy is an uncommon but potentially vision-threatening complication of MFCPU.

Purpose of the Study:

  • To characterize the clinical presentation and outcomes of patients experiencing optic neuropathy secondary to MFCPU.
  • To evaluate treatment strategies for optic neuropathy in MFCPU patients.

Main Methods:

  • Retrospective case series analysis of eight patients (11 eyes) with MFCPU and optic neuropathy.
  • Review of clinical data and treatment responses.

Main Results:

  • Optic neuropathy in MFCPU patients was responsive to corticosteroid treatment.
  • Corticosteroids were often necessary for long-term management to prevent recurrence.
  • Immunosuppressive therapy was effective in preventing recurrent optic neuropathy.
  • Visual acuity improved or stabilized in the majority of affected eyes (9/11) with treatment.

Conclusions:

  • Optic neuropathy is an infrequent complication of MFCPU associated with significant visual morbidity.
  • Immunosuppressive therapy is crucial for preventing recurrent optic neuropathy and preserving vision in MFCPU patients.