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Stevens-Johnson syndrome induced by doxycycline
Natalie N Cac1, Michael J Messingham, Patrick J Sniezek
1Department of Dermatology, University of Iowa, Iowa City, USA.
Cutis
|March 29, 2007
Summary
Stevens-Johnson syndrome (SJS), a severe skin reaction, is rarely linked to tetracycline antibiotics. This case highlights doxycycline, a common tetracycline, as a potential trigger for SJS in adults.
Area of Science:
- Dermatology
- Pharmacology
- Toxicology
Background:
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe mucocutaneous reactions often triggered by medications.
- Commonly implicated drug classes include anticonvulsants, sulfonamides, penicillins, allopurinol, and NSAIDs.
- Tetracycline-associated SJS is exceptionally rare in medical literature.
Observation:
- A 46-year-old male patient presented with symptoms consistent with SJS.
- The patient had recently been prescribed and was taking doxycycline, a tetracycline antibiotic.
Findings:
- The clinical presentation and temporal association strongly suggested doxycycline as the causative agent for SJS.
- This case underscores the potential for doxycycline to induce SJS, despite its rarity.
Implications:
- Highlights the importance of considering less common drug triggers for SJS.
- Informs clinicians about the potential risk of doxycycline-induced SJS.
- Contributes to the pharmacovigilance of tetracycline antibiotics regarding severe cutaneous adverse reactions.
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