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Updated: Jul 16, 2026

A Comprehensive Pipeline to Assess the Efficiency of Human Erythropoiesis In Vitro and Ex Vivo
Published on: January 10, 2025
Polycythemia and increased erythropoietin in a patient with chronic kidney disease
Simone Stark1, Björn Winkelmann, Christof Kluthe
1Department of Neonatology, University Hospital Charité of Berlin, Germany.
Background:
A 16-year-old white male with a history of obstructive uropathy presented to a pediatric outpatient clinic with a first syncope. At presentation, he had a hemoglobin level of 220 g/l, a serum erythropoietin level of 27.4 U/l and a serum creatinine level of 200.7 micromol/l (2.27 mg/dl).
Investigations:
Physical examination, serum laboratory analysis, renal ultrasound, MRI, and 99mTc-MAG3 scintigraphy of the kidneys.
Diagnosis:
Chronic renal insufficiency caused by obstructive hydronephrosis and accompanied by increased erythropoietin levels of renal origin and polycythemia.
Management:
Serial phlebotomies and laparoscopic removal of the right hydronephrotic kidney.
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