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Updated: Jul 16, 2026

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
Published on: July 18, 2016
Volume-targeted ventilation of newborns
Jaideep Singh1, Sunil K Sinha, Steven M Donn
1James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK.
Abstract:
Traditional management of neonatal respiratory failure has been accomplished with mechanical ventilation delivered by time-cycled, pressure-limited techniques. Although easy to use, this modality results in the delivery of tidal volumes that vary according to pulmonary compliance. In contrast, volume-targeted ventilation delivers a selected tidal volume at variable peak inspiratory pressure, resulting in consistent tidal volume delivery, even in the face of changing compliance. This article reviews salient features of volume-targeted ventilation and a review of the evidence base.
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