Related Experiment Video
Updated: Jul 15, 2026
08:50
Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
The supercharged microvascular jejunal interposition
Stephen G Swisher1, Wayne L Hofstetter, Michael J Miller
1Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. sswisher@mdanderson.org
Seminars in Thoracic and Cardiovascular Surgery
|April 4, 2007
Summary
For patients needing esophageal replacement without gastric conduits, the supercharged jejunum (SPJ) offers a viable alternative. This complex reconstruction, when performed by experienced teams, shows acceptable morbidity and potential long-term benefits.
Area of Science:
- Surgical reconstruction of the esophagus.
Background:
- Traditional gastric conduits are unsuitable for esophageal replacement in certain patients due to disease or prior surgery.
- Alternative esophageal reconstruction methods are needed for complex cases.
Observation:
- The supercharged jejunum (SPJ) presents an option for total esophageal reconstruction when gastric conduits are unavailable.
- Colonic interposition is another alternative conduit.
Findings:
- Esophageal reconstruction using SPJ is feasible in select patients.
- Acceptable morbidity and potential long-term functional benefits are associated with SPJ.
- Experienced surgical teams familiar with microvascular reconstruction are crucial for successful outcomes.
Implications:
- The SPJ provides a valuable option for complex esophageal reconstruction.
- Careful surgical technique is essential to minimize risks associated with SPJ.
- Further understanding of SPJ indications and technical nuances can improve patient outcomes.
Related Concept Videos
01:07Intestinal Obstruction II: Pathophysiology
Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
01:15Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
01:29Intestinal Obstruction I: Introduction
Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
00:55Microvilli
Microvilli are tiny finger-like projections found on the surface of certain cells. Their purpose is to increase the surface area of the cell's apical surface, resulting in more effective absorption or secretion of substances.
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity to...
These microvilli are predominantly present in cells lining the small intestine, kidney tubules, and certain cells in the respiratory and reproductive systems. By significantly expanding the surface area of the cell membrane, microvilli enhance the cell's capacity to...
01:15Small Intestine
The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique C-shape wraps...
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique C-shape wraps...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD: