[Prostate-specific antigen in serum and prostate epithelium in benign prostatic hyperplasia]

The aim of our investigation was the simultaneous study of concentration of prostate-specific antigen (PSA) in serum and its immune-histochemical expression in the adenomatous prostatic tissue. 50 patients have been investigated. In 48 patients benign prostatic hyperplasia (BPH) has been diagnosed, and 2 patients served as controls. Investigated patients were divided by 2 groups: 1st group--patients with moderate IPSS (n=6); 2nd group--patients with expressed IPSS (n=42). The results of our investigations shown that at any variant of BPH lumine epithelium, as a rule, were PSA-positive. Negativity of immune-histochemical reaction was observed in areas of epithelium atypical hyperplasia, when proliferated epithelium is presented by basal cells. Expression degree varied between weak, moderate and high. The comparison of PSA expression degrees in tissue and its blood levels shown that the change of blood concentrations was more variable, than expression in tissue. Quantitative imbalance between them indicates that determination of blood PSA without immune-histochemical investigation is less reliable and does not give a valuable insight about the essence prostate pathology.