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Levofloxacin implants with predefined microstructure fabricated by three-dimensional printing technique.

Weidong Huang1, Qixin Zheng, Wangqiang Sun

  • 1Institue of Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China.

International Journal of Pharmaceutics
|April 7, 2007
PubMed
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Novel 3D printing creates advanced drug implants with complex release profiles. This technology offers significant advantages over conventional methods for fabricating sophisticated drug delivery systems.

Area of Science:

  • Biomaterials Engineering
  • Drug Delivery Systems
  • Additive Manufacturing

Background:

  • Conventional drug implants often lack control over drug release kinetics.
  • Designing implants with complex, multi-phasic release profiles remains a challenge.
  • Rapid prototyping of customized drug delivery devices is highly desirable.

Purpose of the Study:

  • To develop and optimize a novel 3D printing technique for fabricating drug implants.
  • To achieve complex, bi-modal drug release profiles (pulsatile and steady-state) from a single implant.
  • To compare the efficacy of 3D printed implants against conventionally fabricated ones.

Main Methods:

  • Utilized a lactic acid polymer matrix with a predefined microstructure for 3D printing.
  • Optimized process parameters, focusing on binder selection (ethanol and acetone mixture).

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  • Fabricated levofloxacin (LVFX) implants and analyzed their in vitro release profiles and morphologies using ESEM and UV spectrophotometry.

    • Main Results:

    • Successfully prepared LVFX implants with a bi-modal release profile using 3D printing.
    • Demonstrated both pulsatile (days 5-25, 50-80) and steady-state (days 25-50) release from a single implant.
    • 3D printing enabled fabrication of sophisticated micro- and macro-architectures, outperforming conventional methods.

    Conclusions:

    • 3D printing technology is effective for creating drug implants with complex release profiles.
    • Predefined microstructures fabricated via 3D printing offer significant advantages over conventional methods.
    • This technique allows for rapid prototyping and fabrication of customized drug delivery devices.