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Plasma cell myeloma presenting as abnormal uterine bleeding
Loveleen C Kang1, David B Thomas, Jingchuan Wang
1Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33647, USA. kanglc@moffitt.usf.edu
Summary
This study details a rare case where abnormal uterine bleeding and anemia were the first signs of plasma cell myeloma, a systemic cancer. Early detection through gynecological examination is crucial for diagnosing this condition.
Area of Science:
- Gynecologic Oncology
- Hematology
- Pathology
Background:
- Plasma cell myeloma is a malignant proliferation of plasma cells, typically affecting the bone marrow.
- Abnormal uterine bleeding is a common gynecological complaint, often associated with various benign and malignant conditions.
Observation:
- A 53-year-old woman presented with anemia and abnormal uterine bleeding.
- Endometrial and cervical biopsies showed infiltration by large atypical cells, identified as neoplastic plasma cells.
Findings:
- The patient was diagnosed with systemic plasma cell dyscrasia, also known as plasma cell myeloma.
- The gynecological symptoms were the initial presentation of the underlying plasma cell myeloma.
Implications:
- This case highlights the importance of considering systemic hematologic malignancies in the differential diagnosis of abnormal uterine bleeding.
- Prompt gynecological evaluation and biopsy can lead to early diagnosis of plasma cell myeloma.
- Understanding atypical presentations of plasma cell myeloma is crucial for timely patient management.
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