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Updated: Jul 15, 2026
14:09
Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
Orthostatic tremor in progressive supranuclear palsy
Rob M A de Bie1, Robert Chen, Anthony E Lang
1Movement Disorders Center, Division of Neurology, Toronto Western Hospital, Toronto, Ontario, Canada.
Summary
Orthostatic tremor (OT) patients can develop progressive supranuclear palsy (PSP). This case highlights a patient with OT, restless legs syndrome, and evolving PSP symptoms, suggesting a potential link.
Area of Science:
- Neurology
- Movement Disorders
Background:
- Orthostatic tremor (OT) is a rare condition characterized by tremor during standing.
- Patients are classified as primary OT or OT plus, based on associated neurological features.
Observation:
- A patient presented with OT, postural arm tremor, and restless legs syndrome (RLS).
- This patient subsequently developed clinical features characteristic of progressive supranuclear palsy (PSP).
Findings:
- The case describes a patient with a combination of OT, RLS, and emergent PSP.
- This presentation expands the understanding of neurological comorbidities associated with OT.
Implications:
- Progressive supranuclear palsy (PSP) can manifest with or be accompanied by orthostatic tremor.
- This case underscores the importance of recognizing overlapping symptoms in neurodegenerative disorders.
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