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Updated: Jul 15, 2026

Use of High-Throughput Automated Microbioreactor System for Production of Model IgG1 in CHO Cells
Published on: September 28, 2018
A fully automated robotic system for high throughput fermentation
Hartmut F Zimmermann1, Jochen Rieth
1Degussa AG, Creavis Technologies & Innovation, Hanau, Wolfgang, Germany. hartmut.zimmermann@degussa.com <hartmut.zimmermann@degussa.com>
Abstract:
High throughput robotic systems have been used since the 1990s to carry out biochemical assays in microtiter plates. However, before the application of such systems in industrial fermentation process development, some important specific demands should be taken into account. These are sufficient oxygen supply, optimal growth temperature, minimized sample evaporation, avoidance of contaminations, and simple but reliable process monitoring. A fully automated solution where all these aspects have been taken into account is presented.
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