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A fully automated robotic system for high throughput fermentation.

Hartmut F Zimmermann1, Jochen Rieth

  • 1Degussa AG, Creavis Technologies & Innovation, Hanau, Wolfgang, Germany. hartmut.zimmermann@degussa.com <hartmut.zimmermann@degussa.com>

Clinics in Laboratory Medicine
|April 10, 2007
PubMed
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High throughput robotic systems automate biochemical assays. A new automated solution addresses key industrial fermentation demands like oxygen supply and contamination control for improved process development.

Area of Science:

  • Biotechnology
  • Biochemical Engineering
  • Process Automation

Background:

  • High throughput robotic systems have been utilized for biochemical assays since the 1990s.
  • Industrial fermentation process development presents unique challenges not fully addressed by existing systems.

Purpose of the Study:

  • To present a fully automated solution for industrial fermentation process development.
  • To address critical demands including oxygen supply, temperature control, evaporation minimization, contamination avoidance, and process monitoring.

Main Methods:

  • Development of a fully automated robotic system.
  • Integration of specific modules to manage oxygen supply, temperature, and evaporation.
  • Implementation of contamination control measures.

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  • Incorporation of simple and reliable process monitoring tools.

    • Main Results:

    • The presented automated solution effectively manages critical parameters for industrial fermentation.
    • Demonstrated successful integration of oxygen supply, temperature control, and evaporation minimization.
    • Achieved reliable process monitoring and contamination avoidance.

    Conclusions:

    • The developed automated system meets the specific demands of industrial fermentation process development.
    • This solution offers a robust platform for optimizing fermentation processes.
    • Automation is key to advancing efficient and reliable industrial fermentation.