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A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration

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Drug-induced Sweet's syndrome.

Dennis F Thompson¹, Kristin E Montarella

¹Department of Pharmacy Practice, College of Pharmacy, Southwestern Oklahoma State University, Weatherford, OK 73103, USA. dennis.thompson@swosu.edu

The Annals of Pharmacotherapy

|April 12, 2007

Summary

This review identifies granulocyte colony-stimulating factor (G-CSF), all-trans retinoic acid (ATRA), and vaccines as associated with drug-induced Sweet's syndrome (SS). Evidence for other drugs is insufficient.

Area of Science:

Dermatology
Pharmacology
Clinical Medicine

Background:

Sweet's syndrome (SS), also known as acute febrile neutrophilic dermatosis, is an inflammatory condition.
Drug-induced SS is a recognized but less common presentation of the disorder.
Identifying causative agents is crucial for patient management and understanding disease mechanisms.

Purpose of the Study:

To systematically review and assess the literature on medications implicated in causing Sweet's syndrome.
To evaluate the causality and strength of evidence for various drug-associated SS cases.
To identify drugs with a plausible pharmacologic mechanism for inducing SS.

Main Methods:

Comprehensive literature search of MEDLINE, International Pharmaceutical Abstracts, Science Citation Index, and EMBASE databases (up to December 2006).

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Inclusion of all case reports of drug-induced SS for causality assessment using an expanded Naranjo scale.

Review of relevant articles for background information and additional citations from bibliographies.

Main Results:

Granulocyte colony-stimulating factor (G-CSF), all-trans retinoic acid (ATRA), and vaccines met criteria for association with SS.
Sufficient data and plausible pharmacologic mechanisms support the association for G-CSF and ATRA.
While minocycline has high-quality evidence, quantity and mechanistic data are lacking; other miscellaneous drugs lack sufficient evidence.

Conclusions:

G-CSF, ATRA, and vaccines are significantly associated with drug-induced Sweet's syndrome.
Further research may be needed to clarify the role of certain drugs like minocycline.
This review provides a framework for evaluating drug causality in SS cases.