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Related Experiment Videos

Reproducible coronary plaque quantification by multislice computed tomography.

Nico Bruining1, Jos R T C Roelandt, Alessandro Palumbo

  • 1Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands. n.Bruining@erasmusmc.nl

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|April 12, 2007
PubMed
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Computer-assisted coronary plaque measurements using multislice computed tomography coronary angiography (QMSCT-CA) showed no significant differences in repeated measurements. However, QMSCT-CA underestimates lumen and vessel dimensions compared to intravascular ultrasound (IVUS).

Area of Science:

  • Cardiology
  • Medical Imaging
  • Computational Biology

Background:

  • Assessing coronary artery disease requires accurate plaque measurement.
  • Multislice computed tomography coronary angiography (QMSCT-CA) is a developing technology for this purpose.
  • Investigating the accuracy and reproducibility of QMSCT-CA is crucial for clinical application.

Purpose of the Study:

  • To evaluate the reproducibility and accuracy of computer-assisted coronary plaque measurements using QMSCT-CA.
  • To compare QMSCT-CA measurements with quantitative intravascular ultrasound (QCU).

Main Methods:

  • Forty-eight patients with symptomatic coronary artery disease were analyzed.
  • QMSCT-CA was performed twice by two investigators, and QCU was performed by a third, all blinded.

Related Experiment Videos

  • Volumetric measurements of lumen, vessel, and plaque were compared between QMSCT-CA and QCU.

    • Main Results:

    • No significant differences were found in matched region of interest lengths between QMSCT-CA and QCU.
    • Significant differences were observed in lumen and vessel volumetric measurements (P < 0.001).
    • Plaque volumetric measurements showed significant differences for one investigator (P = 0.02) but not the other (P = 0.07).
    • Automated lumen detection in QMSCT-CA improved results compared to QCU (P < 0.001).
    • Inter-investigator variability for QMSCT-CA measurements was not statistically significant.

    Conclusions:

    • QMSCT-CA systematically underestimates coronary lumen and vessel dimensions compared to QCU.
    • Repeated QMSCT-CA plaque measurements demonstrated no significant differences, despite scattered results.
    • Automated lumen detection in QMSCT-CA offers improved accuracy over manual measurements.